Search results for " alpha-defensin"

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Over-expression of paneth cell-derived anti-microbial peptides in the gut of patients with ankylosing spondylitis and subclinical intestinal inflamma…

2010

OBJECTIVES: Subclinical gut inflammation has been demonstrated in patients with AS. Altered expression of paneth cell (PC) anti-microbial peptides have been reported in the inflamed ileum of patients with Crohn's disease (CD). Here, we investigated the expression of PC-derived peptides in subclinical gut inflammation in AS. METHODS: Multiple adjacent mucosal biopsies from terminal ileum were obtained from 25 patients with AS, 30 CD and 15 healthy controls (HCs). Expression of human α-defensin 5 (HD-5), phospholipase A2 (PLA2), lysozyme and SOX-9 molecules was assessed by quantitative Taqman RT-PCR on mucosal samples. Immunohistochemistry with anti-human HD-5 antibody and genotyping of relev…

AdultMalePaneth CellsPathologymedicine.medical_specialtyGene ExpressionInflammationIleumdigestive systemRheumatologyNOD2ankylosing spondylitismedicineHumansSpondylitis AnkylosingPharmacology (medical)IleitisPrecordial catch syndromeSubclinical infectionPaneth cellInnate immune systembusiness.industryMiddle Agedmedicine.diseaseGastroenteritisPaneth cells alpha-defensin ankylosing spondylitismedicine.anatomical_structureCase-Control StudiesPaneth cellImmunologyalpha-defensinFemalemedicine.symptombusinessAntimicrobial Cationic PeptidesRheumatology

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